| Name | Pos | Team | Status |
|---|---|---|---|
| Ike Hill | WR | MIA | ACT |
| Ike Hilliard | WR | TB | ACT |
| Ike Readon | DL | MIA | ACT |
| Ike Reese | LB | ATL | ACT |
| Ike Taylor | DB | PIT | ACT |
| Ike Thomas | DB | BUF | ACT |
| Ikem Ekwonu | OL | CAR | ACT |
| Ilm Manning | OL | CAR | ACT |
| Ira Albright | RB | BUF | ACT |
| Ira Gordon | OL | LAC | ACT |
| Ira Hillary | WR | MIN | ACT |
| Ira Matthews | RB | LV | ACT |
| Ira Valentine | RB | HOU | ACT |
| Irv Eatman | OL | HOU | ACT |
| Irv Goode | OL | MIA | ACT |
| Irv Smith | TE | CLE | ACT |
| Irvin Charles | WR | NYJ | ACT |
| Irvin Phillips | DB | LV | ACT |
| Irving Fryar | WR | WAS | ACT |
| Irving Spikes | RB | MIA | ACT |
| Isaac Alarcon | OL | SF | ACT |
| Isaac Asiata | OL | MIA | ACT |
| Isaac Bruce | WR | SF | ACT |
| Isaac Byrd | WR | CAR | ACT |
| Isaac Curtis | WR | CIN | ACT |
| Isaac Fruechte | WR | MIN | ACT |
| Isaac Guerendo | RB | SF | ACT |
| Isaac Hagins | WR | TB | ACT |
| Isaac Seumalo | OL | ARI | ACT |
| Isaac Snell | DL | DEN | ACT |
| Isaac Sopoaga | DL | NE | ACT |
| Isaac Sowells | OL | CLE | ACT |
| Isaac TeSlaa | WR | DET | ACT |
| Isaac Yiadom | DB | NO | ACT |
| Isaia Glass | OL | CAR | ACT |
| Isaiah Adams | OL | ARI | ACT |
| Isaiah Bond | WR | CLE | ACT |
| Isaiah Davis | RB | NYJ | ACT |
| Isaiah Ford | WR | MIA | ACT |
| Isaiah Foskey | DL | CIN | ACT |
| Isaiah Green | DB | PIT | ACT |
| Isaiah Hodgins | WR | NYG | ACT |
| Isaiah Iton | DL | NE | ACT |
| Isaiah Jatta | OL | LV | ACT |
| Isaiah Johnson | DB | TB | ACT |
| Isaiah Kacyvenski | LB | LA | ACT |
| Isaiah Land | LB | DAL | ACT |
| Isaiah Likely | TE | NYG | ACT |
| Isaiah McDuffie | LB | GB | ACT |
| Isaiah McGuire | DL | CLE | ACT |